Palakkad is well connected by roads. National Highway 47 from Salem to Kanyakumari and the Palakkad-Kozhikode State Highway 213 pass through the district. Another important road is the Palakkad-Ponnani which connects NH 47 and NH 17.
Palakkad is a railway junction on India's Southern railway. Coimbatore is the nearest major station. The cities of Pollachi, Dindigul and Madurai are connected by the meter gauge line starting from here. Trains on this line bring vegetables, fish and dairy products from other cities.
The nearest airport is at Coimbatore, 52 km from Palakkad. The nearest international airport is the Cochin (Kochi) International airport, 120 km from Palakkad.